We are interested in using chemistry to understand biological processes. Central to our theme is organic chemistry as a tool that intersects with molecular life sciences such as molecular and cell biology. Our primary focus is the development of chemical toolboxes to address problems in biology. Currently, our work is aimed at the following:
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Development of novel diboron reagents for the mild and selective boration of activated carbon-carbon bonds
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Development of medium-sized branched peptides to target RNA structures associated with HIV as the next generation anti-HIV therapeutics
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Defining the roles of sphingosine kinases in hyperproliferative diseases by developing cell permeable small molecule libraries as probes
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Development of N-terminal peptidic boronic acids as protease inhibitors
Acknowledgements
We are grateful for the generous support of our work by:
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